* [Blog](https://origin-researchcenter.paloaltonetworks.com/blog) * [Palo Alto Networks](https://origin-researchcenter.paloaltonetworks.com/blog/corporate/) * [AI Security](https://origin-researchcenter.paloaltonetworks.com/blog/category/ai-security/) * New Cortex XDR Integratio... # New Cortex XDR Integration with Claude Cowork Secures Desktop AI Agents [](https://www.facebook.com/sharer/sharer.php?u=https%3A%2F%2Forigin-researchcenter.paloaltonetworks.com%2Fblog%2F2026%2F11%2Fnew-cortex-xdr-integration-with-claude-cowork-secures-desktop-ai-agents%2F) [](https://twitter.com/share?text=New+Cortex+XDR+Integration+with+Claude+Cowork+Secures+Desktop+AI+Agents&url=https%3A%2F%2Forigin-researchcenter.paloaltonetworks.com%2Fblog%2F2026%2F11%2Fnew-cortex-xdr-integration-with-claude-cowork-secures-desktop-ai-agents%2F) [](https://www.linkedin.com/shareArticle?mini=true&url=https%3A%2F%2Forigin-researchcenter.paloaltonetworks.com%2Fblog%2F2026%2F11%2Fnew-cortex-xdr-integration-with-claude-cowork-secures-desktop-ai-agents%2F&title=New+Cortex+XDR+Integration+with+Claude+Cowork+Secures+Desktop+AI+Agents&summary=&source=) [](https://www.paloaltonetworks.com//www.reddit.com/submit?url=https://origin-researchcenter.paloaltonetworks.com/blog/2026/11/new-cortex-xdr-integration-with-claude-cowork-secures-desktop-ai-agents/&ts=markdown) \[\](mailto:?subject=New Cortex XDR Integration with Claude Cowork Secures Desktop AI Agents) Link copied By [Daphna Shemesh](https://www.paloaltonetworks.com/blog/author/daphna-shemesh/?ts=markdown "Posts by Daphna Shemesh") Nov 02, 2026 3 minutes [AI Security](https://www.paloaltonetworks.com/blog/category/ai-security/?ts=markdown) [Partners](https://www.paloaltonetworks.com/blog/category/partners/?ts=markdown) [Products and Services](https://www.paloaltonetworks.com/blog/category/products-and-services/?ts=markdown) AI agents working directly on the desktop offer new ways to automate complex tasks, yet they operate outside traditional endpoint controls and pose unacceptable risks to many security leaders. Today, we're announcing a new [Cortex XDR integration](https://support.claude.com/en/articles/17828685-run-your-endpoint-detection-and-response-edr-sensor-in-claude-cowork-on-claude-desktop) with Claude Cowork to deliver visibility and threat detection for this new agentic workspace. Claude Cowork brings agentic capabilities directly to desktop applications as part of Claude Enterprise. Instead of responding to a single prompt, it plans and completes multi-step tasks by reading files, navigating applications and executing workflows. This work takes place inside a small, local virtual machine that is designed to act as a security boundary. However, this isolation also prevents the EDR agent from monitoring the agent's activity. With this integration, XDR bridges that gap to deliver deep visibility and threat detection across local agentic workflows without compromising host security. ## Delivering Runtime Visibility and Threat Detection Inside the Virtual Machine With this new integration with Claude Cowork, we're bringing XDR directly into the virtual machine using a lightweight sensor. XDR will extend runtime visibility into the agent's actions, tracking accessed systems, file changes and executed commands while detecting and preventing malicious behavior in real time. Behind this protection, XDR brings together Unit 42 Threat intelligence and machine learning models trained on global telemetry to block zero day threats by default. To prevent alert fatigue, the sensor feeds virtual machine telemetry directly into XDR analytics, automatically correlating related events into unified incident stories. The Cortex platform will consolidate the agent's activity from inside the virtual machine and tie it back to the desktop in a single view. This gives security teams complete context into agent's actions alongside the rest of their endpoint data. ## Securing Every Agent on the Endpoint EDR coverage across all execution environments is a baseline requirement for enterprise security teams, but it's no longer sufficient if it doesn't secure AI agents. Just as we brought together XDR and Cortex Agentic Endpoint Security to protect both traditional system processes and AI agents with [XDR One](https://www.paloaltonetworks.com/blog/2026/10/reinventing-endpoint-security-with-cortex-xdr-one/), through this integration with Claude Cowork we are once again expanding XDR to seamlessly monitor every agent on the endpoint. The integration will be available in private preview in the coming months. This integration builds on our broader work securing AI across the enterprise. Palo Alto Networks is a launch participant in Anthropic's [Project Glasswing](https://www.anthropic.com/glasswing), an initiative that gives a small group of organizations that build or maintain critical software early access to frontier AI capabilities for defensive cybersecurity. Earlier this year, we introduced [Prisma AIRS Unified Data Protection for Claude](https://www.paloaltonetworks.com/blog/2026/08/prisma-airs-unified-data-protection-for-claude/) to monitor prompts across Claude Code, Claude.ai, and Claude Cowork for data leaks and prompt injections. Now, with Cortex XDR extending into Claude Cowork, security teams can protect data in transit to Claude and monitor agent activity directly on the endpoint. [PROTECT THE MODERN ENDPOINT](https://www.paloaltonetworks.com/cortex/cortex-xdr) *** ** * ** *** ***Forward-Looking Statements*** *This blog contains forward-looking statements that involve risks, uncertainties and assumptions, including, without limitation, statements regarding the benefits, impact, or performance or potential benefits, impact or performance of our products and technologies or future products and technologies.* *Any unreleased services or features (and any services or features not generally available to customers) referenced in this or other press releases or public statements are not currently available (or are not yet generally available to customers) and may not be delivered when expected or at all. Customers who purchase Palo Alto Networks applications should make their purchase decisions based on services and features currently generally available.* *** ** * ** *** ## Related Blogs ### [AI Security](https://www.paloaltonetworks.com/blog/category/ai-security/?ts=markdown), [Announcement](https://www.paloaltonetworks.com/blog/category/announcement/?ts=markdown), [Partners](https://www.paloaltonetworks.com/blog/category/partners/?ts=markdown), [Products and Services](https://www.paloaltonetworks.com/blog/category/products-and-services/?ts=markdown) [#### Advancing Agentic AI Security with Palo Alto Networks and NVIDIA](https://origin-researchcenter.paloaltonetworks.com/blog/2026/10/advancing-agentic-ai-security-with-palo-alto-networks-and-nvidia/) ### [AI Security](https://www.paloaltonetworks.com/blog/category/ai-security/?ts=markdown), [Announcement](https://www.paloaltonetworks.com/blog/category/announcement/?ts=markdown), [Partners](https://www.paloaltonetworks.com/blog/category/partners/?ts=markdown), [Products and Services](https://www.paloaltonetworks.com/blog/category/products-and-services/?ts=markdown), [Unit 42](https://unit42-dev2.paloaltonetworks.com) [#### Unit 42 Expands Frontier AI Defense with Armadin Partnership](https://origin-researchcenter.paloaltonetworks.com/blog/2026/04/unit-42-frontier-ai-defense-armadin-partnership/) ### [AI Security](https://www.paloaltonetworks.com/blog/category/ai-security/?ts=markdown), [Announcement](https://www.paloaltonetworks.com/blog/category/announcement/?ts=markdown), [Partners](https://www.paloaltonetworks.com/blog/category/partners/?ts=markdown), [Products and Services](https://www.paloaltonetworks.com/blog/category/products-and-services/?ts=markdown) [#### Securing the Enterprise AI Ecosystem with ServiceNow and Prisma AIRS](https://origin-researchcenter.paloaltonetworks.com/blog/2026/03/securing-enterprise-ai-ecosystem-servicenow-prisma-airs/) ### [AI Security](https://www.paloaltonetworks.com/blog/category/ai-security/?ts=markdown), [Announcement](https://www.paloaltonetworks.com/blog/category/announcement/?ts=markdown), [Company and Culture](https://www.paloaltonetworks.com/blog/category/company-culture/?ts=markdown), [Partners](https://www.paloaltonetworks.com/blog/category/partners/?ts=markdown), [Products and Services](https://www.paloaltonetworks.com/blog/category/products-and-services/?ts=markdown) [#### Securing Every Identity in the Age of AI](https://origin-researchcenter.paloaltonetworks.com/blog/2026/02/securing-every-identity-in-the-age-of-ai/) ### [AI Security](https://www.paloaltonetworks.com/blog/category/ai-security/?ts=markdown), [Announcement](https://www.paloaltonetworks.com/blog/category/announcement/?ts=markdown), [Partners](https://www.paloaltonetworks.com/blog/category/partners/?ts=markdown), [Products and Services](https://www.paloaltonetworks.com/blog/category/products-and-services/?ts=markdown) [#### The Power of Glean and Prisma AIRS Integration](https://origin-researchcenter.paloaltonetworks.com/blog/2026/02/power-of-glean-and-prisma-airs-integration/) ### [AI Application Security](https://www.paloaltonetworks.com/blog/network-security/category/ai-application-security/?ts=markdown), [AI Security](https://www.paloaltonetworks.com/blog/category/ai-security/?ts=markdown), [Announcement](https://www.paloaltonetworks.com/blog/category/announcement/?ts=markdown), [Next-Generation Firewalls](https://www.paloaltonetworks.com/blog/network-security/category/next-generation-firewalls/?ts=markdown), [Partners](https://www.paloaltonetworks.com/blog/category/partners/?ts=markdown), [Products and Services](https://www.paloaltonetworks.com/blog/category/products-and-services/?ts=markdown) [#### Palo Alto Networks Announces Support for NVIDIA Enterprise AI Factory](https://origin-researchcenter.paloaltonetworks.com/blog/2026/01/support-nvidia-enterprise-ai-factory/) ### Subscribe to the Blog! 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