Artificial intelligence has shifted to being the primary engine for market leadership. To compete, enterprises are shifting from general-purpose computing to AI factories, specialized infrastructures designed to manage the entire lifecycle of AI. However, this transition requires robust security without sacrificing performance and efficiency.
We are proud to announce that Palo Alto Networks Prisma® AIRS™, accelerated on the NVIDIA BlueField data processing unit (DPU), is now part of the NVIDIA Enterprise AI Factory validated design.
The integrated solution embeds zero trust security directly into the AI infrastructure, providing comprehensive protection without impacting AI performance. By deploying Palo Alto Networks Prisma® AIRS™ Network Intercept directly onto the NVIDIA BlueField and extending to the cloud, Prisma AIRS establishes an essential zero trust governance fabric for the AI factory, enabling enterprises to accelerate innovation while maintaining control.
This critical architectural shift enables optimal AI performance and infrastructure efficiency by offloading security processing to an isolated domain, while leveraging the DPU's hardware acceleration via NVIDIA DOCA to enforce security policies at line speed. The implementation also leverages real-time workload information captured using DOCA Argus, which is then passed to Cortex XSIAM® where it is used for AI-driven responses using the Cortex XSOAR® orchestration platform.
Rich Campagna, SVP Product Management, Palo Alto Networks said:
The AI Factory is the new engine for value creation, and securing it is a board-level imperative. The validation of Palo Alto Networks Prisma AIRS accelerated with NVIDIA BlueField within the NVIDIA Enterprise AI Factory enables a new security architecture for the AI era. We are embedding trust directly into the infrastructure, giving leaders the confidence to safeguard their proprietary intelligence and deploy AI bravely.
Kevin Deierling, senior vice president of Networking at NVIDIA said:
AI is transforming every industry and security must evolve to protect AI factories. To be scalable, security must be distributed and embedded within the AI infrastructure. This is achieved with NVIDIA BlueField running Palo Alto Networks Prisma AIRS to deliver robust, runtime security for the AI factory, with optimal AI performance and efficiency.
Deploy AI Bravely with a Future-Proof Foundation
The Future of Secure AI Factories

In addition to deploying Palo Alto Networks Prisma AIRS on NVIDIA BlueField in a distributed model, it’s essential to maintain a centralized Hyperscale Security Firewall (HSF) cluster at the ingress and egress points of the AI factory to enforce a defense-in-depth strategy. Beyond network segmentation, individual workloads can selectively route traffic through hyperscale clusters to detect advanced application-layer threats and prevent lateral movement. These hyperscale firewall clusters scale elastically with demand, delivering session resiliency and the high availability required for critical AI operations.
This architecture fundamentally improves the Total Cost of Ownership (TCO) for AI infrastructure. By isolating security functions on BlueField, enterprises enable 100% of host computing resources to be dedicated to AI applications. This elimination of resource contention allows the AI Factory to maximize token throughput and capital efficiency.
This validated design is the blueprint for immediate efficiency. It provides a seamless path for enterprises to shift from general-purpose clusters to secure AI factory infrastructure without costly overhauls. More importantly, this collaboration establishes an unparalleled roadmap for future-proofing your investment. By securing operations with the high-performance NVIDIA BlueField-3 today, the architecture is inherently ready for the next generation, NVIDIA BlueField-4. This forward compatibility helps AI factories immediately handle gigascale demands, scaling up to 6X the compute power and doubling the bandwidth when BlueField-4 becomes available.
The inclusion of the Palo Alto Networks Prisma AIRS platform in the NVIDIA Enterprise AI Factory Validated Design bolsters enterprise AI security. By establishing the zero trust governance fabric of Prisma AIRS runtime security on NVIDIA BlueField, organizations gain a comprehensive defense. Proprietary and sensitive data is secured throughout the entire stack, and models are protected from adversarial threats, such as prompt injection attacks. With Prisma AIRS, the world's most comprehensive AI security platform, leaders gain the confidence to innovate and deploy AI bravely. This validated design is the essential blueprint for securely accelerating your market leadership without compromising security.